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Febrile Antigen

Titration of patient’s antibodies by agglutination of known bacteria suspensions is valuable in the evaluation of certain diseases. By using known bacteria suspensions with known concentrations, we can use the agglutination reaction that will occur with the patient’s antibodies to evaluate their antibody level. Antibodies produced as a response to a febrile infection can be detected in a similar fashion. The term “febrile” is associated with several organisms that produce a fever in the host. 

Many antibodies are formed when humans fight disease. Among these antibodies are the agglutinins, which are combined with the agglutinogen (homologous antigen) to cause agglutination. Agglutination forms visible clumps of bacteria.  


The Febrile Antigen suspensions are suitable for both the rapid slide and tube agglutination tests, which both detect agglutinins. Febrile Antigen suspensions are killed bacteria, stained to enhance the reading of the test. The somatic ‘O’ antigens are stained blue while the flagellar ‘H’ antigens are stained red. 

SDS   |   Package Inserts: Proteus and Pulse

Salmonella Group O (A, B, C, D)
  • Salmonella infections: 1.35 million yearly in the U.S. causing 26,500 hospitalizations and 420 deaths. Food is the main source of infection. 

Salmonella Group H (A, B, C, D)
  • High risk in Asia and Africa

Proteus (OX2, OX19, OXK)
  • The Pulse Febrile Antigen suspensions identify and quantify specific antibodies in human serum found following infection with certain Proteus pathogens. Proteus is a urinary tract infection.


Positive/Negative Control
  • Control is available in any size.

  • The usual size is 5ml in a vial with dropper, however, bulk reagent is also available.

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